Prolonged and intensive treatment may cause local atropic changes in the skin such as striae, thinning, and dilatation of the superficial blood vessels, particularly when occlusive dressings are used or when skin folds are involved. Prolonged use of large amounts, or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercorticism, and is more likely to occur in infants and children or if occlusive dressings (or napkin) are used. In rare instances, treatment of psoriasis (or its withdrawal) is thought to have provoked the pustular form of the disease. Betamethasone is usually well tolerated, but if signs of hypersensitivity appear, therapy should stop immediately.
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